Bleeding Edge Biotech

There was a time in structural biology when solving protein structures using NMR was received with considerable skepticism. In addition to the normal experimental uncertainty, the technique generated structures with additional uncertainty due to the vibrational motions of proteins in solution. That’s part of the reason standard NMR entries in the PDB contain ~20 structures while x-ray structures have just one. However modern NMR methods have advanced to the point that few skeptics are left. The two techniques together were essential in the rapid increase of structural information that’s available today.

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